In this episode, Dr. Andrew Huberman welcomes Dr. Craig Heller, a distinguished Professor of Biology at Stanford University and a leading expert in temperature regulation. They delve into the intricate science of how the body and brain manage temperature, debunking common myths about cooling and heating. Dr. Heller reveals optimal, science-backed strategies to combat hyperthermia and hypothermia, significantly boosting endurance and weight training performance through precise body cooling. The discussion highlights how his lab's innovations have tripled anaerobic performance and eliminated delayed onset muscle soreness in athletes. Listeners will discover how cooling the brain can reduce inflammation, enhance sleep, and improve cognition, offering practical tools and mechanistic insights applicable to everyone, including pets, for superior health and performance.