Understanding and treating severe neurological and psychiatric disorders like autism, epilepsy, and schizophrenia using stem cell-derived brain models (organoids and assembloids).

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About this podcast

In this enlightening episode of the Huberman Lab podcast, host Andrew Huberman interviews Dr. Sergiu Pașca, an MD and Professor of Psychiatry and Behavioral Sciences at Stanford University. Dr. Pașca, a pioneer in the field, delves into the complex biology and genetics of autism, exploring the reasons behind the rising diagnostic rates and discussing cutting-edge research. The conversation focuses on his groundbreaking work with "organoids and assembloids" – human stem cell-derived brain models that are revolutionizing the study and potential treatment of profound autism, epilepsy, and schizophrenia. The episode also addresses critical ethical and safety considerations surrounding the use of gene editing and stem cell therapies in humans, offering listeners an in-depth look into the future of neuroscience and psychiatric treatment.